Unsteady Reynolds averaged Navier-Stokes equations are solved to analyze the aerodynamical interaction effects between propeller and wing based on dynamic patched grid. Numerical simulations are conducted on three geometric configurations, which are isolated propeller with nacelle, propeller installed on the wing with nacelle and the nacelle with wing respectively. For the isolated propeller, swirls in slipstream flow pass periodically. While they are disturbed by the wing after the propeller is installed. The vorticity distributions are altered and very complex flow structures are induced especially near nacelle. The aerodynamic characteristics of wing are influenced since the local angles of attack are changed by the swirls in slipstream. Slipstream at lower advance ratio produces larger impaction on wing pressure distribution. Additionally, the wing drag develops with sinusoidal fluctuations as the propeller rotates. On the other side, the blade thrust increases a little with two oscillations during a rotation period due to the wing presence.