中国计划到2045年实现地面与轨道间以及轨道与轨道间的航班化航天运输。跨域飞行器因其具有的跨速域、跨空域、跨介质域能力，可实现航班化天地往返运输，其特殊的战略价值已经受到各国的高度重视。跨域飞行器飞行过程中需要经历多个高速、复杂的飞行阶段，对导航系统的可靠性和安全性提出了更高要求。因此，亟需发展面向航班化航天运输的跨域飞行器自主导航方法，提升跨域飞行器自主导航能力。针对这一问题，提出了一种基于惯性/天文深度融合的跨域飞行器异构多源组合导航方法，以解决跨域飞行器在实现航班化航天运输中的自主导航问题。结果表明，所提方法能够充分利用惯性导航和天文导航优势互补的特点，对导航误差进行修正，有效提升跨域飞行器导航系统在复杂飞行环境下的输出精度和可靠性，保证跨域飞行器导航系统的安全可靠运行，提升其全飞行阶段中导航系统信息无缝融合能力，为实现航班化航天运输的构想进行技术积累。

China plans to achieve airline-flight-mode space transportation between ground and orbit， as well as between orbit and orbit by 2045. Cross domain vehicles， due to their ability to cross speed， airspace， and media domains， can achieve flight-based back-and-forth transportation between space and earth. Their special strategic value have been highly valued by countries around the world. The flight process of cross domain vehicles requires multiple high-speed and complex flight stages， which puts higher requirements on the reliability and safety of navigation systems. Therefore， there is an urgent need to develop autonomous navigation methods for cross domain vehicles for airline-flight-mode space transportation. To address this issue， this paper proposes a heterogeneous multi-source integrated navigation method for cross domain vehicles based on inertial/celestial deep fusion to solve the autonomous navigation problem of cross domain vehicles in achieving flight oriented space transportation. The results show that the method proposed can fully utilize the complementary advantages of inertial navigation and celestial navigation， correct navigation errors， effectively improve the output accuracy and reliability of cross domain vehicles navigation systems in complex flight environments， ensure the safe and reliable operation of navigation systems of cross domain vehicles， and enhance their seamless information fusion ability in the entire flight stage， accumulating technologies for realizing the concept of airline-flight-mode space transportation.