The aerodynamic environment and other external conditions of the missile are complex and changeable. The deep supervised learning guidance algorithm with excellent performance in the specific aerodynamic environment cannot be directly applied to the new environment, which brings great challenges to the accurate prediction of guidance instructions. To solve the above problems, this paper proposes a Transfer-learning-based Impact-angel Constraint with Time-minimum Guidance algorithm (TICTG) for missile midcourse guidance which minimizes impact time under impact angle constraints. The proposed algorithm can quickly adapt the guidance law to different aerodynamic conditions with very little new data. Firstly, we extract key features insensitive to aerodynamic changes from ballistic data in different aerodynamic environments by training feature extractor and domain dis-criminator against domain ground. Secondly, we also design bias acceleration predictor adapted to different aero-dynamic conditions, so as to achieve accurate guidance of the missile. A large number of numerical simulation results show that this method can still achieve accurate guidance instruction prediction in the new aerodynamic environment.